| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Anplagghed al cinema | $2,786,367 | - | 525 | - | $5,307 | $2,786,367 | 1 | Medusa Distribuzione | true | false |
| 2 | 1 | My Super Ex-Girlfriend | $969,953 | -34.9% | 247 | -6 | $3,926 | $2,889,428 | 2 | 20th Century Fox International | false | false |
| 3 | 4 | Marie Antoinette | $668,949 | -9.2% | 164 | -346 | $4,078 | $1,742,645 | 2 | Sony Pictures Releasing | false | false |
| 4 | 2 | The Departed | $556,105 | -38.6% | 180 | -85 | $3,089 | $10,661,605 | 5 | Medusa Distribuzione | false | false |
| 5 | 3 | Children of Men | $529,166 | -33.3% | 216 | -6 | $2,449 | $1,617,125 | 2 | United International Pictures | false | false |
| 6 | 5 | You, Me and Dupree | $437,379 | -39% | 190 | -15 | $2,301 | $2,836,064 | 3 | United International Pictures | false | false |
| 7 | 6 | The Devil Wears Prada | $402,791 | -40.7% | 152 | -59 | $2,649 | $18,178,259 | 7 | 20th Century Fox International | false | false |
| 8 | - | Pan's Labyrinth | $379,237 | - | 151 | - | $2,511 | $379,237 | 1 | Warner Bros. | true | false |
| 9 | 7 | Over the Hedge | $367,502 | -42% | 234 | -67 | $1,570 | $8,835,390 | 5 | United International Pictures | false | false |
| 10 | 9 | The Wind that Shakes the Barley | $280,655 | -20.4% | 121 | -4 | $2,319 | $1,356,732 | 3 | BIM Distribuzione | false | false |
| 11 | 11 | Quale amore | $210,054 | -24.2% | 120 | -3 | $1,750 | $586,976 | 2 | 01 Distribution | false | false |
| 12 | - | Shortbus | $201,174 | - | 90 | - | $2,235 | $201,174 | 1 | BIM Distribuzione | true | false |
| 13 | 8 | Flags of Our Fathers | $172,956 | -54.8% | 127 | -83 | $1,361 | $1,513,051 | 3 | Warner Bros. | false | false |
| 14 | 12 | The Unknown Woman | $149,758 | -34.5% | 64 | -50 | $2,339 | $4,561,329 | 6 | Medusa Distribuzione | false | false |
| 15 | 10 | Ma l'amore... sì! | $146,660 | -57.7% | 138 | -54 | $1,062 | $611,181 | 2 | Eagle Pictures | false | false |
| 16 | 15 | Babel | $113,252 | -34% | 36 | -34 | $3,145 | $3,079,300 | 5 | 01 Distribution | false | false |
| 17 | 14 | The Family Friend | $105,927 | -40.3% | 60 | -55 | $1,765 | $842,244 | 3 | Medusa Distribuzione | false | false |
| 18 | 17 | Chestnut: Hero of Central Park | $91,465 | -21.8% | 20 | -8 | $4,573 | $247,327 | 2 | Mediafilm | false | false |
| 19 | 16 | Our Country | $79,635 | -35.1% | 41 | -28 | $1,942 | $1,036,309 | 4 | 01 Distribution | false | false |
| 20 | - | Fascisti su Marte | $49,671 | - | 35 | - | $1,419 | $1,059,366 | 5 | Fandango | false | false |
