| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | My Super Ex-Girlfriend | $1,489,064 | - | 253 | - | $5,885 | $1,489,064 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | The Departed | $906,060 | -32.8% | 265 | -108 | $3,419 | $9,627,256 | 4 | Medusa Distribuzione | false | false |
| 3 | - | Children of Men | $793,613 | - | 222 | - | $3,574 | $793,613 | 1 | United International Pictures | true | false |
| 4 | - | Marie Antoinette | $736,883 | - | 510 | - | $1,444 | $736,883 | 1 | Sony Pictures Releasing | true | false |
| 5 | 2 | You, Me and Dupree | $716,679 | -35.2% | 205 | +8 | $3,495 | $2,153,829 | 2 | United International Pictures | false | false |
| 6 | 4 | The Devil Wears Prada | $679,563 | -30.4% | 211 | -52 | $3,220 | $17,203,948 | 6 | 20th Century Fox International | false | false |
| 7 | 3 | Over the Hedge | $633,377 | -38.9% | 301 | -82 | $2,104 | $8,194,246 | 4 | United International Pictures | false | false |
| 8 | 5 | Flags of Our Fathers | $383,009 | -34.5% | 210 | -2 | $1,823 | $1,187,306 | 2 | Warner Bros. | false | false |
| 9 | 7 | The Wind that Shakes the Barley | $352,772 | -15.7% | 125 | +3 | $2,822 | $934,596 | 2 | BIM Distribuzione | false | false |
| 10 | - | Ma l'amore... sì! | $347,079 | - | 192 | - | $1,807 | $347,079 | 1 | Eagle Pictures | true | false |
| 11 | - | Quale amore | $277,129 | - | 123 | - | $2,253 | $277,129 | 1 | 01 Distribution | true | false |
| 12 | 10 | The Unknown Woman | $228,648 | -34.6% | 114 | -55 | $2,005 | $4,235,998 | 5 | Medusa Distribuzione | false | false |
| 13 | 6 | The Grudge 2 | $200,145 | -57.9% | 158 | -93 | $1,266 | $820,614 | 2 | 01 Distribution | false | false |
| 14 | 11 | The Family Friend | $177,335 | -42.6% | 115 | -46 | $1,542 | $632,320 | 2 | Medusa Distribuzione | false | false |
| 15 | 9 | Babel | $171,670 | -51.2% | 70 | -94 | $2,452 | $2,839,314 | 4 | 01 Distribution | false | false |
| 16 | 13 | Our Country | $122,721 | -50.2% | 69 | -62 | $1,778 | $901,374 | 3 | 01 Distribution | false | false |
| 17 | - | Chestnut: Hero of Central Park | $116,955 | - | 28 | - | $4,176 | $116,955 | 1 | Mediafilm | true | false |
| 18 | 12 | Trust the Man | $111,289 | -63.8% | 75 | -35 | $1,483 | $1,076,099 | 3 | Moviemax | false | false |
| 19 | 8 | The Lazarus Child | $101,139 | -74.2% | 62 | -154 | $1,631 | $1,744,619 | 3 | Eagle Pictures | false | false |
| 20 | - | The Lost City | $89,239 | - | 107 | - | $834 | $89,239 | 1 | Buena Vista International | true | false |
