| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Departed | $1,349,078 | -31.9% | 373 | -49 | $3,616 | $8,274,376 | 3 | Medusa Distribuzione | false | false |
| 2 | - | You, Me and Dupree | $1,105,521 | - | 197 | - | $5,611 | $1,105,521 | 1 | United International Pictures | true | false |
| 3 | 2 | Over the Hedge | $1,036,737 | -43.2% | 383 | -67 | $2,706 | $7,396,358 | 3 | United International Pictures | false | false |
| 4 | 3 | The Devil Wears Prada | $975,898 | -32.8% | 263 | -50 | $3,710 | $16,273,472 | 5 | 20th Century Fox International | false | false |
| 5 | - | Flags of Our Fathers | $584,619 | - | 212 | - | $2,757 | $584,619 | 1 | Warner Bros. | true | false |
| 6 | - | The Grudge 2 | $474,990 | - | 251 | - | $1,892 | $475,148 | 1 | 01 Distribution | true | false |
| 7 | - | The Wind that Shakes the Barley | $418,236 | - | 122 | - | $3,428 | $420,333 | 1 | BIM Distribuzione | true | false |
| 8 | 4 | The Lazarus Child | $391,740 | -55.5% | 216 | -34 | $1,813 | $1,530,217 | 2 | Eagle Pictures | false | false |
| 9 | 5 | Babel | $351,483 | -45.3% | 164 | -92 | $2,143 | $2,530,451 | 3 | 01 Distribution | false | false |
| 10 | 6 | The Unknown Woman | $349,488 | -36.2% | 169 | -64 | $2,067 | $3,884,178 | 4 | Medusa Distribuzione | false | false |
| 11 | - | The Family Friend | $308,966 | - | 161 | - | $1,919 | $310,320 | 1 | Medusa Distribuzione | true | false |
| 12 | 8 | Trust the Man | $307,522 | -17.3% | 110 | +10 | $2,795 | $863,007 | 2 | Moviemax | false | false |
| 13 | 9 | Our Country | $246,497 | -28.1% | 131 | -9 | $1,881 | $704,172 | 2 | 01 Distribution | false | false |
| 14 | 7 | World Trade Center | $193,131 | -55.5% | 120 | -46 | $1,609 | $6,917,657 | 5 | United International Pictures | false | false |
| 15 | 10 | Scoop | $129,556 | -37.4% | 45 | -26 | $2,879 | $5,595,044 | 6 | Medusa Distribuzione | false | false |
| 16 | 11 | Secret Journey | $117,855 | -42.3% | 46 | -56 | $2,562 | $418,062 | 2 | Medusa Distribuzione | false | false |
| 17 | 12 | Fascisti su Marte | $101,532 | -42.6% | 61 | -7 | $1,664 | $816,397 | 3 | Fandango | false | false |
| 18 | - | Azur & Asmar: The Princes' Quest | $91,899 | - | 130 | - | $706 | $92,622 | 1 | Lucky Red | true | false |
| 19 | 13 | Any Reason Not to Marry? | $49,996 | -58.5% | 41 | -13 | $1,219 | $215,383 | 2 | Warner Bros. | false | false |
| 20 | 14 | Salvatore - Questa è la vita | $48,287 | -54.6% | 44 | -10 | $1,097 | $261,281 | 2 | Buena Vista International | false | false |
