| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Devil Wears Prada | $6,113,340 | - | 447 | - | $13,676 | $6,113,340 | 1 | 20th Century Fox International | true | false |
| 2 | - | The Departed | $4,299,931 | - | 363 | - | $11,845 | $4,299,931 | 1 | Entertainment Film Distributors | true | false |
| 3 | 1 | Click | $2,388,692 | -28.8% | 400 | -2 | $5,971 | $7,171,250 | 2 | Sony Pictures Releasing | false | false |
| 4 | 2 | Hoodwinked! | $1,706,397 | -48.2% | 436 | +1 | $3,913 | $5,494,529 | 2 | Momentum Pictures | false | false |
| 5 | 3 | World Trade Center | $1,618,801 | -48% | 413 | +2 | $3,919 | $6,350,421 | 2 | United International Pictures | false | false |
| 6 | 5 | The Queen | $950,004 | -36.7% | 335 | -10 | $2,835 | $10,353,626 | 4 | Pathé | false | false |
| 7 | 4 | Children of Men | $867,512 | -51.5% | 332 | -40 | $2,612 | $7,406,902 | 3 | United International Pictures | false | false |
| 8 | - | Accepted | $654,625 | - | 249 | - | $2,629 | $654,625 | 1 | United International Pictures | true | false |
| 9 | 7 | Little Miss Sunshine | $317,181 | -40.3% | 132 | -39 | $2,402 | $4,809,444 | 5 | 20th Century Fox International | false | false |
| 10 | 6 | Talladega Nights: The Ballad of Ricky Bobby | $196,125 | -68.8% | 183 | -158 | $1,071 | $5,983,452 | 4 | Sony Pictures Releasing | false | false |
| 11 | 8 | Little Man | $156,677 | -63.3% | 196 | -76 | $799 | $7,844,144 | 6 | Sony Pictures Releasing | false | false |
| 12 | 9 | You, Me and Dupree | $90,784 | -75% | 99 | -148 | $917 | $15,020,271 | 7 | United International Pictures | false | false |
| 13 | 13 | An Inconvenient Truth | $88,410 | -47.4% | 68 | +2 | $1,300 | $1,070,337 | 4 | United International Pictures | false | false |
| 14 | 18 | Volver | $80,567 | -35.1% | 32 | -21 | $2,517 | $4,752,831 | 7 | Pathé | false | false |
| 15 | 12 | Life and Lyrics | $71,162 | -60.2% | 55 | -15 | $1,293 | $321,126 | 2 | United International Pictures | false | false |
| 16 | 14 | Monster House | $65,527 | -54.6% | 177 | -86 | $370 | $12,126,982 | 9 | Sony Pictures Releasing | false | false |
| 17 | 16 | Cars | $60,627 | -53.6% | 146 | -79 | $415 | $30,353,869 | 11 | Buena Vista International | false | false |
| 18 | 10 | The Black Dahlia | $59,643 | -74.8% | 51 | -118 | $1,169 | $3,176,305 | 4 | Entertainment Film Distributors | false | false |
| 19 | 11 | Dirty Sanchez: The Movie | $52,191 | -74.8% | 71 | -117 | $735 | $1,180,466 | 3 | Pathé | false | false |
| 20 | 19 | Garfield: A Tail of Two Kitties | $48,341 | -53.2% | 122 | -81 | $396 | $12,027,033 | 12 | 20th Century Fox International | false | false |
| 21 | 20 | Pirates of the Caribbean: Dead Man's Chest | $36,825 | -56.1% | 36 | -42 | $1,022 | $97,244,964 | 14 | Buena Vista International | false | false |
| 22 | - | Zidane - A 21st Century Portrait | $35,375 | - | 20 | - | $1,768 | $160,415 | 2 | Artificial Eye | false | false |
| 23 | 17 | Clerks II | $24,752 | -80.1% | 30 | -135 | $825 | $919,288 | 3 | United International Pictures | false | false |
| 24 | - | Deep Sea | $22,470 | - | 2 | - | $11,235 | $2,154,088 | 32 | IMAX | false | false |
| 25 | - | Lage Raho Munna Bhai | $20,471 | - | 15 | - | $1,364 | $1,514,896 | 6 | Eros Worldwide | false | false |
| 26 | - | Waris Shah: Ishq Daa Waaris | $19,471 | - | 10 | - | $1,947 | $64,331 | 2 | - | false | false |
| 27 | - | Dil Apna Punjabi | $15,927 | - | 7 | - | $2,275 | $458,509 | 6 | - | false | false |
| 28 | - | Brothers of the Head | $15,641 | - | 15 | - | $1,042 | $15,641 | 1 | Tartan | true | false |
| 29 | - | Superman Returns | $15,527 | - | 6 | - | $2,587 | $30,157,106 | 13 | Warner Bros. | false | false |
| 30 | - | Zindanggi Rocks | $14,556 | - | 10 | - | $1,455 | $14,556 | 2 | Eros Worldwide | false | false |
| 31 | - | The Wind that Shakes the Barley | $13,579 | - | 15 | - | $905 | $7,055,697 | 16 | Pathé | false | false |
| 32 | - | Mannat | $13,396 | - | 9 | - | $1,488 | $13,396 | 1 | Eros Worldwide | true | false |
| 33 | - | John Tucker Must Die | $12,000 | - | 25 | - | $480 | $7,201,480 | 8 | 20th Century Fox International | false | false |
| 34 | - | Neil Young: Heart of Gold | $11,615 | - | 5 | - | $2,323 | $11,615 | 1 | United International Pictures | true | false |
| 35 | 15 | Trust the Man | $10,913 | -92% | 21 | -175 | $519 | $1,116,247 | 3 | Icon Film Distribution | false | false |
| 36 | - | Over the Hedge | $10,907 | - | 34 | - | $320 | $24,317,020 | 15 | United International Pictures | false | false |
| 37 | - | Stormbreaker | $9,903 | - | 25 | - | $396 | $12,500,077 | 12 | Entertainment Film Distributors | false | false |
| 38 | - | Driving Lessons | $8,825 | - | 21 | - | $420 | $226,950 | 5 | Tartan | false | false |
| 39 | - | The Sentinel | $8,662 | - | 15 | - | $577 | $3,828,286 | 6 | 20th Century Fox International | false | false |
| 40 | - | The Ant Bully | $8,107 | - | 29 | - | $279 | $3,672,350 | 10 | Warner Bros. | false | false |
| 41 | - | Man Push Cart | $7,877 | - | 3 | - | $2,625 | $7,877 | 1 | Periscoop Film | true | false |
| 42 | - | Crank | $7,476 | - | 13 | - | $575 | $2,933,706 | 6 | United International Pictures | false | false |
| 43 | - | Snow Cake | $7,429 | - | 7 | - | $1,061 | $148,481 | 5 | Momentum Pictures | false | false |
| 44 | - | Quinceañera | $6,857 | - | 10 | - | $685 | $48,563 | 2 | - | false | false |
| 45 | - | Isolation | $4,584 | - | 16 | - | $286 | $38,599 | 2 | Lionsgate Films | false | false |
| 46 | - | Mountain Patrol 2006 Re-release | $3,936 | - | 1 | - | $3,936 | $16,077 | 2 | Axiom Films | false | false |
| 47 | - | Keane 2006 Re-release | $3,854 | - | 3 | - | $1,284 | $52,756 | 3 | Soda Pictures | false | false |
| 48 | - | The Night Listener | $3,828 | - | 5 | - | $765 | $1,341,506 | 4 | Icon Film Distribution | false | false |
| 49 | - | Miami Vice | $3,815 | - | 3 | - | $1,271 | $13,786,307 | 10 | United International Pictures | false | false |
| 50 | - | A Scanner Darkly | $3,396 | - | 6 | - | $566 | $1,737,132 | 8 | Warner Bros. | false | false |
