| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Pirates of the Caribbean: Dead Man's Chest | $4,146,327 | -56.1% | 845 | -32 | $4,906 | $19,122,606 | 2 | Buena Vista International | false | false |
| 2 | - | The Break-Up | $1,732,079 | - | 297 | - | $5,831 | $1,732,079 | 1 | United International Pictures | true | false |
| 3 | - | Perfume: The Story of a Murderer | $1,049,469 | - | 335 | - | $3,132 | $1,051,271 | 1 | Medusa Distribuzione | true | false |
| 4 | 2 | Cars | $738,893 | -51.2% | 269 | -85 | $2,746 | $15,426,397 | 5 | Buena Vista International | false | false |
| 5 | 3 | The Queen | $392,614 | -51.1% | 188 | -3 | $2,088 | $1,509,825 | 2 | BIM Distribuzione | false | false |
| 6 | - | Golden Door | $371,685 | - | 110 | - | $3,378 | $379,835 | 1 | 01 Distribution | true | false |
| 7 | 4 | The Missing Star | $287,567 | -63.3% | 199 | -68 | $1,445 | $245,230 | 3 | 01 Distribution | false | false |
| 8 | 6 | The Stone Merchant | $182,539 | -62.1% | 154 | -61 | $1,185 | $853,662 | 2 | Medusa Distribuzione | false | false |
| 9 | 5 | Superman Returns | $166,196 | -74.7% | 138 | -149 | $1,204 | $6,838,253 | 4 | Warner Bros. | false | false |
| 10 | - | Little Miss Sunshine | $164,606 | - | 68 | - | $2,420 | $164,606 | 1 | 20th Century Fox International | true | false |
| 11 | - | The Ant Bully | $164,549 | - | 147 | - | $1,119 | $164,631 | 1 | Warner Bros. | true | false |
| 12 | 7 | Lucky Number Slevin | $149,277 | -64.1% | 73 | -65 | $2,044 | $4,426,859 | 6 | Moviemax | false | false |
| 13 | - | Dreamer | $111,373 | - | 128 | - | $870 | $111,525 | 1 | Eagle Pictures | true | false |
| 14 | 9 | Thank You for Smoking | $91,403 | -63.5% | 40 | -45 | $2,285 | $1,427,220 | 4 | Lucky Red | false | false |
| 15 | 8 | Pulse | $67,219 | -82.6% | 54 | -151 | $1,244 | $1,283,648 | 3 | Eagle Pictures | false | false |
| 16 | 10 | Garfield: A Tail of Two Kitties | $27,982 | -76.2% | 49 | -47 | $571 | $4,044,333 | 6 | 20th Century Fox International | false | false |
| 17 | 14 | Belle toujours | $21,970 | -48.7% | 15 | -4 | $1,464 | $147,105 | 3 | Mikado Film | false | false |
| 18 | 12 | The Road to Guantanamo | $18,834 | -68.1% | 24 | -14 | $784 | $118,887 | 2 | Fandango | false | false |
| 19 | 13 | Quinceañera | $15,078 | -67.9% | 11 | -7 | $1,370 | $218,184 | 4 | Teodora Film | false | false |
| 20 | - | The Orchestra of Piazza Vittorio | $14,675 | - | 8 | - | $1,834 | $34,385 | 2 | Lucky Red | false | false |
