| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The 40-Year-Old Virgin | $3,236,007 | - | 394 | - | $8,213 | $3,236,007 | 1 | United International Pictures | true | false |
| 2 | - | Red Eye | $1,641,593 | - | 354 | - | $4,637 | $1,641,593 | 1 | United International Pictures | true | false |
| 3 | 2 | Charlie and the Chocolate Factory | $1,216,437 | -39.5% | 457 | -55 | $2,661 | $64,528,079 | 6 | Warner Bros. | false | false |
| 4 | 1 | The Dukes of Hazzard | $1,138,695 | -63.3% | 437 | -10 | $2,605 | $6,186,473 | 2 | Warner Bros. | false | false |
| 5 | - | The Business | $978,176 | - | 279 | - | $3,506 | $978,176 | 1 | Pathé | true | false |
| 6 | 4 | Crash | $762,968 | -29.2% | 274 | -7 | $2,784 | $7,895,975 | 4 | Pathé | false | false |
| 7 | 3 | Bewitched | $636,090 | -44.8% | 369 | -35 | $1,723 | $6,999,129 | 3 | Sony Pictures Releasing | false | false |
| 8 | 6 | Herbie Fully Loaded | $580,351 | -25.6% | 405 | -23 | $1,432 | $10,004,776 | 5 | Buena Vista International | false | false |
| 9 | 8 | The Adventures of Sharkboy and Lavagirl 3-D | $533,337 | -25.9% | 301 | -1 | $1,771 | $2,043,066 | 2 | Sony Pictures Releasing | false | false |
| 10 | 5 | The Cave | $476,263 | -53.1% | 276 | - | $1,725 | $2,496,931 | 2 | Entertainment Film Distributors | false | false |
| 11 | 7 | The Island | $297,297 | -61.3% | 252 | -111 | $1,179 | $8,976,780 | 4 | Warner Bros. | false | false |
| 12 | 9 | Madagascar | $222,367 | -48.6% | 303 | -48 | $733 | $41,106,995 | 8 | United International Pictures | false | false |
| 13 | 11 | Wedding Crashers | $136,103 | -63.1% | 116 | -136 | $1,173 | $23,980,625 | 8 | Entertainment Film Distributors | false | false |
| 14 | 14 | No Entry | $134,836 | -19.1% | 33 | -1 | $4,085 | $486,743 | 2 | Eros Worldwide | false | false |
| 15 | 10 | Unleashed | $117,072 | -72% | 136 | -127 | $860 | $2,500,956 | 3 | United International Pictures | false | false |
| 16 | - | On a Clear Day | $106,847 | - | 72 | - | $1,483 | $106,847 | 1 | Icon Film Distribution | true | false |
| 17 | 12 | Fantastic Four | $104,001 | -62.7% | 206 | -84 | $504 | $23,121,723 | 7 | 20th Century Fox International | false | false |
| 18 | - | Last Days | $74,061 | - | 30 | - | $2,468 | $74,061 | 1 | Optimum Releasing | true | false |
| 19 | 17 | Me and You and Everyone We Know | $70,666 | -43.3% | 21 | -7 | $3,365 | $558,179 | 3 | Optimum Releasing | false | false |
| 20 | 13 | The Sisterhood of the Traveling Pants | $66,181 | -66.8% | 143 | -34 | $462 | $537,474 | 2 | Warner Bros. | false | false |
