| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Sin City | $1,032,717 | - | 395 | - | $2,614 | $1,906,708 | 1 | Buena Vista International | true | false |
| 2 | 1 | Star Wars: Episode III - Revenge of the Sith | $767,415 | -48.5% | 465 | -139 | $1,650 | $8,419,105 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | Quo Vadis, Baby? | $313,835 | -24.2% | 252 | - | $1,245 | $1,067,263 | 2 | Medusa Distribuzione | false | false |
| 4 | 5 | White Noise | $193,840 | -31.2% | 136 | -2 | $1,425 | $697,392 | 2 | United International Pictures | false | false |
| 5 | 3 | Kung Fu Hustle | $192,946 | -35.8% | 150 | -3 | $1,286 | $704,942 | 2 | Sony Pictures Releasing | false | false |
| 6 | 6 | House of Wax | $169,446 | -14.5% | 154 | -17 | $1,100 | $537,523 | 2 | Warner Bros. | false | false |
| 7 | 4 | Kingdom of Heaven | $161,882 | -43.3% | 142 | -92 | $1,140 | $8,664,419 | 5 | Medusa Distribuzione | false | false |
| 8 | 7 | Once You're Born You Can No Longer Hide | $77,219 | -47.7% | 100 | -81 | $772 | $1,546,044 | 4 | 01 Distribution | false | false |
| 9 | 9 | Downfall | $53,235 | -21.6% | 85 | -15 | $626 | $1,678,806 | 6 | 01 Distribution | false | false |
| 10 | - | I Heart Huckabees | $46,630 | - | 30 | - | $1,554 | $46,630 | 1 | 20th Century Fox International | true | false |
| 11 | 8 | L'uomo perfetto | $38,801 | -44.1% | 52 | -34 | $746 | $1,733,363 | 6 | Warner Bros. | false | false |
| 12 | 20 | The Story of the Weeping Camel | $35,766 | +95% | 23 | +12 | $1,555 | $83,126 | 2 | Fandango | false | false |
| 13 | 14 | Brodeuses: A Common Thread | $35,542 | +17.1% | 19 | +2 | $1,870 | $94,435 | 2 | BIM Distribuzione | false | false |
| 14 | - | Infection | $33,425 | - | 63 | - | $530 | $33,425 | 1 | BIM Distribuzione | true | false |
| 15 | 11 | Modigliani | $33,110 | -47.1% | 49 | -44 | $675 | $981,977 | 4 | Istituto Luce | false | false |
| 16 | - | Steamboy | $29,743 | - | 69 | - | $431 | $29,743 | 1 | Metacinema | true | false |
| 17 | - | Amatemi | $27,399 | - | 20 | - | $1,369 | $27,399 | 1 | Mikado Film | true | false |
| 18 | 16 | Head in the Clouds | $23,717 | -12.4% | 11 | -13 | $2,156 | $1,766,657 | 6 | Moviemax | false | false |
| 19 | - | Triple Agent 2005 Re-release | $22,660 | - | 20 | - | $1,133 | $32,728 | 1 | BIM Distribuzione | true | false |
| 20 | - | Saved! | $21,510 | - | 38 | - | $566 | $21,510 | 1 | Mediafilm | true | false |
