| Rank
| Release
| Opening
| Total Gross
| % of Total
| Theaters
| Average
| Date
| Distributor
|
|---|
| 1 | Sole a catinelle | $25,095,006 | $69,903,094 | 35.9% | 1,121 | $22,386 | Oct 31, 2013 | Medusa Distribuzione |
| 2 | Quo vado? | $24,185,632 | $72,601,522 | 33.3% | 1,212 | $19,955 | Jan 1, 2016 | Medusa Distribuzione |
| 3 | Tolo Tolo | $23,551,220 | $52,186,426 | 45.1% | 1,286 | $18,313 | Jan 1, 2020 | Medusa Distribuzione |
| 4 | Avengers: Endgame | $19,570,574 | $34,145,771 | 57.3% | - | - | Apr 24, 2019 | Walt Disney Pictures |
| 5 | What a Beautiful Day | $15,266,670 | $59,370,498 | 25.7% | 775 | $19,698 | Jan 5, 2011 | Medusa Distribuzione |
| 6 | Avatar | $13,889,941 | $93,746,295 | 14.8% | 848 | $16,379 | Jan 15, 2010 | 20th Century Fox International |
| 7 | Welcome to the North | $12,747,870 | $33,498,625 | 38% | 854 | $14,927 | Jan 17, 2012 | Medusa Distribuzione |
| 8 | The Lion King | $12,212,862 | $42,915,624 | 28.5% | 1,113 | $10,972 | Aug 21, 2019 | Walt Disney Pictures |
| 9 | Alice in Wonderland | $11,115,961 | $39,952,697 | 27.8% | 668 | $16,640 | Mar 3, 2010 | Walt Disney Pictures |
| 10 | The Da Vinci Code | $11,114,109 | $39,197,477 | 28.4% | 910 | $12,213 | May 19, 2006 | Sony Pictures Releasing |
| 11 | The Twilight Saga: Breaking Dawn - Part 2 | $10,557,177 | $24,417,636 | 43.2% | 856 | $12,333 | Nov 15, 2012 | Eagle Pictures |
| 12 | Harry Potter and the Deathly Hallows: Part 1 | $10,193,771 | $24,923,463 | 40.9% | 836 | $12,193 | Nov 19, 2010 | Warner Bros. |
| 13 | The Twilight Saga: New Moon | $9,864,925 | $20,609,171 | 47.9% | 699 | $14,112 | Nov 18, 2009 | Eagle Pictures |
| 14 | Ice Age: Dawn of the Dinosaurs | $9,779,301 | $43,860,019 | 22.3% | 806 | $12,133 | Aug 28, 2009 | 20th Century Fox International |
| 15 | Fifty Shades of Grey | $9,679,857 | $20,498,944 | 47.2% | - | - | Feb 12, 2015 | - |
| 16 | Pirates of the Caribbean: Dead Man's Chest | $9,439,588 | $25,212,003 | 37.4% | 877 | $10,763 | Sep 13, 2006 | Buena Vista International |
| 17 | Spider-Man 3 | $9,406,487 | $26,340,543 | 35.7% | 916 | $10,269 | May 4, 2007 | Sony Pictures Releasing |
| 18 | Spider-Man: No Way Home | $9,305,652 | $28,239,736 | 33% | 523 | $17,792 | Dec 15, 2021 | Sony Pictures Releasing |
| 19 | Iron Man 3 | $9,044,472 | $20,910,968 | 43.2% | 862 | $10,492 | Apr 24, 2013 | Walt Disney Pictures |
| 20 | Avatar: The Way of Water | $8,991,132 | $48,025,161 | 18.7% | 595 | $15,111 | Dec 14, 2022 | Walt Disney Studios Motion Pictures |
| 21 | Barbie | $8,585,116 | $33,902,557 | 25.3% | 484 | $17,737 | Jul 20, 2023 | Sony Pictures Releasing |
| 22 | Si accettano miracoli | $8,537,048 | $17,368,659 | 49.2% | - | - | Dec 31, 2014 | - |
| 23 | I Am Legend | $8,524,364 | $21,020,300 | 40.6% | 486 | $17,539 | Jan 11, 2008 | Warner Bros. |
| 24 | Harry Potter and the Goblet of Fire | $8,486,019 | $24,274,111 | 35% | 697 | $12,175 | Nov 25, 2005 | Warner Bros. |
| 25 | The Twilight Saga: Breaking Dawn - Part 1 | $8,443,854 | $20,016,885 | 42.2% | 719 | $11,743 | Nov 17, 2011 | Eagle Pictures |
| 26 | The Lord of the Rings: The Return of the King | $8,281,016 | $35,837,796 | 23.1% | 736 | $11,251 | Jan 22, 2004 | - |
| 27 | The Simpsons Movie | $8,242,130 | $23,872,009 | 34.5% | 616 | $13,380 | Sep 14, 2007 | 20th Century Fox International |
| 28 | Ho voglia di te | $8,214,552 | $18,594,142 | 44.2% | 575 | $14,286 | Mar 9, 2007 | Warner Bros. |
| 29 | Hancock | $8,045,792 | $17,819,261 | 45.2% | 678 | $11,866 | Sep 12, 2008 | Sony Pictures Releasing |
| 30 | Frozen II | $8,043,806 | $22,460,289 | 35.8% | - | - | Nov 28, 2019 | Walt Disney Pictures |
| 31 | Manual of Love 2 | $8,025,468 | $26,266,668 | 30.6% | 590 | $13,602 | Jan 19, 2007 | Filmauro |
| 32 | Shrek the Third | $8,015,599 | $29,823,042 | 26.9% | 705 | $11,369 | Aug 31, 2007 | Universal Pictures International (UPI) |
| 33 | Minions | $8,014,238 | $26,388,026 | 30.4% | - | - | Aug 27, 2015 | - |
| 34 | The Hangover Part III | $7,952,692 | $16,416,593 | 48.4% | 614 | $12,952 | May 30, 2013 | Warner Bros. |
| 35 | Furious 7 | $7,839,697 | $20,797,031 | 37.7% | - | - | Apr 2, 2015 | - |
| 36 | Spider-Man 2 | $7,758,521 | $24,458,623 | 31.7% | 631 | $12,295 | Sep 16, 2004 | Sony Pictures Releasing |
| 37 | Avengers: Age of Ultron | $7,751,190 | $18,120,047 | 42.8% | - | - | Apr 23, 2015 | - |
| 38 | Harry Potter and the Deathly Hallows: Part 2 | $7,743,448 | $29,775,040 | 26% | 1,008 | $7,681 | Jul 13, 2011 | Warner Bros. |
| 39 | Grande, grosso e... Verdone | $7,659,058 | $21,860,130 | 35% | 703 | $10,894 | Mar 7, 2008 | Filmauro |
| 40 | It | $7,635,649 | $17,400,000 | 43.9% | 686 | $11,130 | Oct 19, 2017 | Warner Bros. |
| 41 | 2012 | $7,603,352 | $21,086,983 | 36.1% | 555 | $13,699 | Nov 13, 2009 | Sony Pictures Releasing |
| 42 | Pirates of the Caribbean: On Stranger Tides | $7,522,955 | $24,461,143 | 30.8% | 949 | $7,927 | May 18, 2011 | Walt Disney Pictures |
| 43 | Star Wars: Episode VII - The Force Awakens | $7,483,161 | $28,508,842 | 26.2% | - | - | Dec 16, 2015 | Walt Disney Pictures |
| 44 | Angels & Demons | $7,474,505 | $26,775,811 | 27.9% | 783 | $9,545 | May 13, 2009 | Sony Pictures Releasing |
| 45 | Pirates of the Caribbean: At World's End | $7,466,711 | $22,456,358 | 33.2% | 909 | $8,214 | May 23, 2007 | Buena Vista International |
| 46 | Fast & Furious 6 | $7,449,695 | $16,681,782 | 44.7% | 666 | $11,185 | May 21, 2013 | United International Pictures |
| 47 | Oppenheimer | $7,442,137 | $31,063,516 | 24% | 515 | $14,450 | Aug 23, 2023 | Universal Pictures International (UPI) |
| 48 | Beauty and the Beast | $7,435,444 | $22,689,495 | 32.8% | 861 | $8,635 | Mar 16, 2017 | Walt Disney Pictures |
| 49 | Avengers: Infinity War | $7,384,164 | $22,837,545 | 32.3% | 976 | $7,565 | Apr 25, 2018 | Walt Disney Pictures |
| 50 | Qualunquemente | $7,350,680 | $22,862,029 | 32.2% | 551 | $13,340 | Jan 21, 2011 | 01 Distribution |
| 51 | Fifty Shades Freed | $7,225,994 | $17,702,008 | 40.8% | 769 | $9,396 | Feb 8, 2018 | Universal Pictures International (UPI) |
| 52 | Ice Age: Continental Drift | $7,202,566 | $21,624,776 | 33.3% | 836 | $8,615 | Sep 27, 2012 | 20th Century Fox International |
| 53 | Skyfall | $7,043,445 | $17,103,042 | 41.2% | 632 | $11,144 | Oct 31, 2012 | Warner Bros. |
| 54 | Despicable Me 2 | $6,994,586 | $21,587,196 | 32.4% | 863 | $8,104 | Oct 10, 2013 | United International Pictures |
| 55 | Kung Fu Panda | $6,957,422 | $22,037,818 | 31.6% | 666 | $10,446 | Aug 29, 2008 | Universal Pictures International (UPI) |
| 56 | The Passion of the Christ | $6,880,664 | $23,919,061 | 28.8% | 553 | $12,442 | Apr 7, 2004 | - |
| 57 | Joker | $6,876,614 | $35,302,504 | 19.5% | 845 | $8,138 | Oct 3, 2019 | Warner Bros. |
| 58 | Fifty Shades Darker | $6,830,852 | $15,796,926 | 43.2% | 779 | $8,768 | Feb 9, 2017 | Universal Pictures International (UPI) |
| 59 | Sorry, If I Love You | $6,808,775 | $20,913,254 | 32.6% | 491 | $13,867 | Jan 25, 2008 | Medusa Distribuzione |
| 60 | Harry Potter and the Half-Blood Prince | $6,795,959 | $26,965,672 | 25.2% | 890 | $7,635 | Jul 15, 2009 | Warner Bros. |
| 61 | Me, Them and Lara | $6,753,283 | $21,347,896 | 31.6% | - | - | Jan 5, 2010 | Warner Bros. |
| 62 | American Sniper | $6,723,739 | $21,390,500 | 31.4% | - | - | Dec 31, 2014 | - |
| 63 | Fantastic Beasts: The Crimes of Grindelwald | $6,688,708 | $14,900,000 | 44.9% | 802 | $8,340 | Nov 15, 2018 | Warner Bros. |
| 64 | The Fate of the Furious | $6,677,151 | $16,416,948 | 40.7% | 521 | $12,816 | Apr 13, 2017 | Universal Pictures International (UPI) |
| 65 | Up | $6,659,543 | $22,494,067 | 29.6% | 652 | $10,214 | Oct 15, 2009 | Walt Disney Pictures |
| 66 | Doctor Strange in the Multiverse of Madness | $6,579,103 | $14,487,541 | 45.4% | 543 | $12,116 | May 4, 2022 | Walt Disney Pictures |
| 67 | Sherlock Holmes | $6,536,572 | $26,955,437 | 24.2% | 394 | $16,590 | Dec 25, 2009 | Warner Bros. |
| 68 | Inside Out | $6,447,262 | $27,140,214 | 23.8% | - | - | Sep 16, 2015 | - |
| 69 | Despicable Me 3 | $6,430,980 | $22,330,417 | 28.8% | 975 | $6,595 | Aug 24, 2017 | Universal Pictures International (UPI) |
| 70 | Finding Dory | $6,424,160 | $17,433,399 | 36.8% | 800 | $8,030 | Sep 15, 2016 | Walt Disney Pictures |
| 71 | The Avengers | $6,372,395 | $22,012,517 | 29% | 679 | $9,384 | Apr 25, 2012 | Walt Disney Pictures |
| 72 | Aladdin | $6,319,712 | $17,103,219 | 37% | 908 | $6,960 | May 22, 2019 | Walt Disney Pictures |
| 73 | Jurassic World | $6,292,565 | $16,723,119 | 37.6% | - | - | Jun 12, 2015 | - |
| 74 | Ratatouille | $6,286,298 | $25,880,003 | 24.3% | 658 | $9,553 | Oct 19, 2007 | Walt Disney Pictures |
| 75 | Harry Potter and the Prisoner of Azkaban | $6,283,045 | $19,460,874 | 32.3% | 637 | $9,863 | Jun 4, 2004 | Warner Bros. |
| 76 | Fantastic Beasts and Where to Find Them | $6,282,422 | $16,200,000 | 38.8% | 783 | $8,023 | Nov 17, 2016 | Warner Bros. |
| 77 | Madagascar: Escape 2 Africa | $6,255,201 | $34,915,869 | 17.9% | 565 | $11,071 | Dec 19, 2008 | Universal Pictures International (UPI) |
| 78 | The Super Mario Bros. Movie | $6,234,300 | $22,040,273 | 28.3% | 562 | $11,093 | Apr 5, 2023 | Universal Pictures International (UPI) |
| 79 | I soliti idioti | $6,197,440 | $13,274,982 | 46.7% | 475 | $13,047 | Nov 3, 2011 | Medusa Distribuzione |
| 80 | Indiana Jones and the Kingdom of the Crystal Skull | $6,190,318 | $18,982,360 | 32.6% | 689 | $8,984 | May 23, 2008 | Universal Pictures International (UPI) |
| 81 | Italians | $6,179,760 | $17,026,331 | 36.3% | 611 | $10,114 | Jan 23, 2009 | Filmauro |
| 82 | Bohemian Rhapsody | $6,127,405 | $32,594,299 | 18.8% | 716 | $8,557 | Nov 29, 2018 | 20th Century Fox International |
| 83 | Harry Potter and the Order of the Phoenix | $6,081,821 | $26,410,993 | 23% | 800 | $7,602 | Jul 11, 2007 | Warner Bros. |
| 84 | Star Wars: Episode IX - The Rise of Skywalker | $6,003,285 | $14,950,148 | 40.2% | - | - | Dec 18, 2019 | Walt Disney Pictures |
| 85 | Notte prima degli esami - Oggi | $5,995,980 | $16,544,856 | 36.2% | 604 | $9,927 | Feb 14, 2007 | 01 Distribution |
| 86 | Madagascar | $5,936,914 | $28,044,781 | 21.2% | 470 | $12,631 | Sep 2, 2005 | United International Pictures |
| 87 | Il mio miglior nemico | $5,891,966 | $23,500,977 | 25.1% | 556 | $10,597 | Mar 10, 2006 | Filmauro |
| 88 | Maleficent | $5,871,396 | $19,094,499 | 30.8% | 650 | $9,032 | May 28, 2014 | Walt Disney Pictures |
| 89 | Il principe abusivo | $5,870,344 | $18,614,277 | 31.5% | 541 | $10,850 | Feb 14, 2013 | 01 Distribution |
| 90 | Sotto una buona stella | $5,821,116 | $14,119,210 | 41.2% | 693 | $8,399 | Feb 13, 2014 | United International Pictures |
| 91 | Meet the Fockers | $5,724,641 | $19,050,339 | 30% | 497 | $11,518 | Feb 11, 2005 | United International Pictures |
| 92 | Immaturi - Il viaggio | $5,722,559 | $15,512,578 | 36.9% | 597 | $9,585 | Jan 6, 2012 | Medusa Distribuzione |
| 93 | The Amazing Spider-Man 2 | $5,706,337 | $12,981,685 | 44% | 811 | $7,036 | Apr 23, 2014 | - |
| 94 | Troy | $5,679,412 | $18,919,343 | 30% | 704 | $8,067 | May 21, 2004 | Warner Bros. |
| 95 | Jumanji: The Next Level | $5,600,051 | $13,979,853 | 40.1% | 634 | $8,832 | Dec 25, 2019 | Sony Pictures Releasing |
| 96 | The Hobbit: An Unexpected Journey | $5,589,351 | $22,378,313 | 25% | 756 | $7,393 | Dec 13, 2012 | Warner Bros. |
| 97 | Natale in crociera | $5,530,201 | $36,800,000 | 15% | 581 | $9,518 | Dec 14, 2007 | Filmauro |
| 98 | It Chapter Two | $5,450,740 | $10,600,000 | 51.4% | 928 | $5,873 | Sep 5, 2019 | Warner Bros. |
| 99 | Star Wars: Episode VIII - The Last Jedi | $5,411,401 | $18,138,020 | 29.8% | 832 | $6,504 | Dec 13, 2017 | Walt Disney Pictures |
| 100 | Captain America: Civil War | $5,404,759 | $12,963,449 | 41.7% | 969 | $5,577 | May 4, 2016 | Walt Disney Pictures |
| 101 | Spectre | $5,385,267 | $13,609,170 | 39.6% | - | - | Nov 6, 2015 | Sony Pictures Releasing |
| 102 | Cinderella | $5,381,181 | $16,178,079 | 33.3% | - | - | Mar 12, 2015 | - |
| 103 | A Boss in the Living Room | $5,357,726 | $16,562,487 | 32.4% | 519 | $10,323 | Jan 1, 2014 | Warner Bros. |
| 104 | L'allenatore nel pallone 2 | $5,321,147 | $11,225,448 | 47.4% | 510 | $10,433 | Jan 11, 2008 | Medusa Distribuzione |
| 105 | The Hunger Games: Mockingjay - Part 1 | $5,308,046 | $11,087,256 | 47.9% | - | - | Nov 20, 2014 | - |
| 106 | Ice Age: The Meltdown | $5,249,504 | $25,985,050 | 20.2% | 538 | $9,757 | Apr 21, 2006 | 20th Century Fox International |
| 107 | Seven Pounds | $5,248,059 | $16,157,223 | 32.5% | 553 | $9,490 | Jan 9, 2009 | Sony Pictures Releasing |
| 108 | Welcome to the South | $5,231,564 | $43,015,634 | 12.2% | 532 | $9,833 | Oct 1, 2010 | Medusa Distribuzione |
| 109 | Women Vs Men | $5,225,989 | $16,719,346 | 31.3% | 624 | $8,374 | Feb 4, 2011 | Medusa Distribuzione |
| 110 | Maleficent: Mistress of Evil | $5,223,918 | $14,291,365 | 36.6% | - | - | Oct 17, 2019 | Walt Disney Pictures |
| 111 | The Wolf of Wall Street | $5,213,122 | $15,963,169 | 32.7% | 560 | $9,309 | Jan 23, 2014 | 01 Distribution |
| 112 | High School Musical 3: Senior Year | $5,188,957 | $12,738,501 | 40.7% | 493 | $10,525 | Oct 31, 2008 | Walt Disney Pictures |
| 113 | Robin Hood | $5,172,957 | $14,676,791 | 35.2% | 667 | $7,755 | May 12, 2010 | United International Pictures |
| 114 | Madagascar 3: Europe's Most Wanted | $5,157,289 | $28,615,036 | 18% | 900 | $5,730 | Aug 22, 2012 | United International Pictures |
| 115 | The Secret Life of Pets | $5,140,471 | $14,810,477 | 34.7% | 515 | $9,981 | Oct 6, 2016 | Universal Pictures International (UPI) |
| 116 | Inferno | $5,069,324 | $13,938,143 | 36.4% | 679 | $7,465 | Oct 13, 2016 | Sony Pictures Releasing |
| 117 | Fast & Furious | $5,057,547 | $11,161,012 | 45.3% | 414 | $12,216 | Apr 17, 2009 | United International Pictures |
| 118 | The Hunger Games: Catching Fire | $5,046,438 | $11,032,504 | 45.7% | 651 | $7,751 | Nov 27, 2013 | United International Pictures |
| 119 | The Dark Knight Rises | $5,029,028 | $18,801,748 | 26.8% | 921 | $5,460 | Aug 29, 2012 | Warner Bros. |
| 120 | Paranormal Activity | $5,019,797 | $9,153,419 | 54.8% | 411 | $12,213 | Feb 5, 2010 | Filmauro |
| 121 | Once Upon a Time... in Hollywood | $5,003,542 | $14,194,432 | 35.2% | 1,016 | $4,924 | Sep 19, 2019 | Warner Bros. |
| 122 | Natale a Beverly Hills | $4,980,522 | $29,916,370 | 16.6% | 607 | $8,205 | Dec 18, 2009 | Filmauro |
| 123 | The Hobbit: The Desolation of Smaug | $4,970,550 | $17,305,657 | 28.7% | 720 | $6,903 | Dec 12, 2013 | Warner Bros. |
| 124 | Twilight | $4,968,259 | $14,410,854 | 34.5% | 551 | $9,016 | Nov 21, 2008 | Eagle Pictures |
| 125 | Thor: The Dark World | $4,964,804 | $11,176,894 | 44.4% | 676 | $7,344 | Nov 20, 2013 | Walt Disney Pictures |
| 126 | The Incredibles | $4,962,920 | $20,286,379 | 24.5% | 524 | $9,471 | Nov 26, 2004 | Buena Vista International |
| 127 | Incredibles 2 | $4,931,536 | $14,646,895 | 33.7% | 853 | $5,781 | Sep 19, 2018 | Walt Disney Pictures |
| 128 | Despicable Me | $4,902,039 | $17,064,781 | 28.7% | 544 | $9,011 | Oct 15, 2010 | United International Pictures |
| 129 | The Nutcracker and the Four Realms | $4,852,749 | $10,540,240 | 46% | 614 | $7,903 | Oct 31, 2018 | Walt Disney Pictures |
| 130 | Natale a New York | $4,844,101 | $30,437,121 | 15.9% | 518 | $9,351 | Dec 15, 2006 | Filmauro |
| 131 | The Twilight Saga: Eclipse | $4,793,904 | $20,711,944 | 23.2% | 788 | $6,083 | Jun 30, 2010 | Eagle Pictures |
| 132 | Fast Five | $4,764,381 | $15,494,242 | 30.8% | 533 | $8,938 | May 4, 2011 | Universal Pictures International (UPI) |
| 133 | Night at the Museum | $4,725,640 | $16,188,874 | 29.2% | 471 | $10,033 | Feb 2, 2007 | 20th Century Fox International |
| 134 | Iron Man 2 | $4,701,280 | $9,979,666 | 47.1% | 581 | $8,091 | Apr 30, 2010 | Paramount Pictures International |
| 135 | The Pursuit of Happyness | $4,697,296 | $21,309,984 | 22% | 391 | $12,013 | Jan 12, 2007 | Medusa Distribuzione |
| 136 | Ex | $4,645,796 | $15,340,865 | 30.3% | 571 | $8,136 | Feb 6, 2009 | 01 Distribution |
| 137 | Natale a Rio | $4,644,058 | $36,125,993 | 12.9% | 592 | $7,844 | Dec 19, 2008 | Filmauro |
| 138 | A Christmas Carol | $4,638,059 | $22,530,311 | 20.6% | 493 | $9,407 | Dec 3, 2009 | Walt Disney Pictures |
| 139 | Hotel Transylvania 3: Summer Vacation | $4,632,927 | $13,849,878 | 33.4% | 660 | $7,019 | Aug 22, 2018 | Warner Bros. |
| 140 | Batman v Superman: Dawn of Justice | $4,620,496 | $12,098,949 | 38.2% | 753 | $6,136 | Mar 24, 2016 | Warner Bros. |
| 141 | Django Unchained | $4,602,531 | $16,283,123 | 28.3% | 541 | $8,507 | Jan 17, 2013 | Warner Bros. |
| 142 | 300 | $4,577,074 | $14,618,081 | 31.3% | 459 | $9,971 | Mar 23, 2007 | Warner Bros. |
| 143 | Captain Marvel | $4,576,917 | $11,458,061 | 39.9% | 773 | $5,920 | Mar 6, 2019 | Walt Disney Pictures |
| 144 | Pirates of the Caribbean: Dead Men Tell No Tales | $4,558,861 | $14,503,644 | 31.4% | 955 | $4,773 | May 24, 2017 | Walt Disney Pictures |
| 145 | Sherlock Holmes: A Game of Shadows | $4,527,952 | $24,533,562 | 18.5% | 551 | $8,217 | Dec 16, 2011 | Warner Bros. |
| 146 | Shrek Forever After | $4,504,291 | $23,451,561 | 19.2% | 793 | $5,680 | Aug 25, 2010 | United International Pictures |
| 147 | Scary Movie 3 | $4,503,126 | $11,038,572 | 40.8% | 369 | $12,203 | Feb 20, 2004 | - |
| 148 | Ice Age: Collision Course | $4,500,873 | $9,693,616 | 46.4% | 1,056 | $4,262 | Aug 22, 2016 | 20th Century Fox International |
| 149 | The Hobbit: The Battle of the Five Armies | $4,494,621 | $15,702,035 | 28.6% | - | - | Dec 18, 2014 | - |
| 150 | The Immature | $4,466,836 | $21,858,834 | 20.4% | 424 | $10,534 | Jan 21, 2011 | Medusa Distribuzione |
| 151 | Minions: The Rise of Gru | $4,459,800 | $15,340,382 | 29.1% | 496 | $8,991 | Aug 18, 2022 | Universal Pictures International (UPI) |
| 152 | Matrimonio alle Bahamas | $4,409,009 | $15,471,233 | 28.5% | 431 | $10,229 | Nov 16, 2007 | Medusa Distribuzione |
| 153 | Kiss Me Again | $4,325,763 | $12,373,612 | 35% | 576 | $7,510 | Jan 29, 2010 | Medusa Distribuzione |
| 154 | Transformers: Revenge of the Fallen | $4,324,077 | $11,685,751 | 37% | 578 | $7,481 | Jun 26, 2009 | United International Pictures |
| 155 | Venom | $4,296,737 | $9,849,263 | 43.6% | 560 | $7,672 | Oct 4, 2018 | Sony Pictures Releasing |
| 156 | Bridget Jones: The Edge of Reason | $4,291,627 | $15,073,062 | 28.5% | 399 | $10,755 | Jan 7, 2005 | United International Pictures |
| 157 | Clash of the Titans | $4,286,144 | $10,275,464 | 41.7% | 533 | $8,041 | Apr 16, 2010 | Warner Bros. |
| 158 | Christmas in South Africa | $4,282,724 | $24,898,572 | 17.2% | 600 | $7,137 | Dec 17, 2010 | Filmauro |
| 159 | Spider-Man: Far from Home | $4,277,622 | $13,498,204 | 31.7% | 874 | $4,894 | Jul 10, 2019 | Warner Bros. |
| 160 | Jurassic World: Fallen Kingdom | $4,272,975 | $12,200,268 | 35% | 898 | $4,758 | Jun 7, 2018 | M2 Pictures |
| 161 | The Hunger Games: Mockingjay - Part 2 | $4,267,835 | $8,884,254 | 48% | - | - | Nov 19, 2015 | - |
| 162 | Men Vs Women | $4,222,767 | $18,452,860 | 22.9% | 572 | $7,382 | Oct 27, 2010 | 01 Distribution |
| 163 | Blessed Madness | $4,222,092 | $10,264,495 | 41.1% | 676 | $6,245 | Jan 11, 2018 | Filmauro |
| 164 | There's No Place Like Home | $4,219,839 | $11,180,791 | 37.7% | 533 | $7,917 | Feb 15, 2018 | 01 Distribution |
| 165 | Creed II | $4,211,550 | $8,300,000 | 50.7% | 524 | $8,037 | Jan 24, 2019 | Warner Bros. |
| 166 | Thor | $4,195,996 | $10,900,780 | 38.5% | 581 | $7,222 | Apr 27, 2011 | Universal Pictures International (UPI) |
| 167 | American Gangster | $4,169,846 | $15,520,131 | 26.9% | 457 | $9,124 | Jan 18, 2008 | Universal Pictures International (UPI) |
| 168 | Cars 3 | $4,161,313 | $9,828,920 | 42.3% | 757 | $5,497 | Sep 14, 2017 | Walt Disney Pictures |
| 169 | A Beautiful Wife | $4,136,919 | $29,502,958 | 14% | 513 | $8,064 | Dec 14, 2007 | Medusa Distribuzione |
| 170 | Shrek 2 | $4,120,875 | $27,503,221 | 15% | 449 | $9,177 | Dec 17, 2004 | United International Pictures |
| 171 | Casino Royale | $4,116,380 | $10,959,793 | 37.6% | 407 | $10,113 | Jan 5, 2007 | Sony Pictures Releasing |
| 172 | A Flat for Three | $4,087,554 | $11,398,541 | 35.9% | 609 | $6,711 | Mar 1, 2012 | Filmauro |
| 173 | Fantastic Four | $4,066,340 | $12,412,822 | 32.8% | 482 | $8,436 | Sep 16, 2005 | 20th Century Fox International |
| 174 | The Ages of Love | $4,057,395 | $9,556,036 | 42.5% | 669 | $6,064 | Feb 25, 2011 | Filmauro |
| 175 | The Batman | $4,027,819 | $10,750,112 | 37.5% | 536 | $7,514 | Mar 3, 2022 | Warner Bros. |
| 176 | Cado dalle nubi | $4,022,708 | $19,573,511 | 20.6% | 424 | $9,487 | Nov 27, 2009 | Medusa Distribuzione |
| 177 | Sorry If I Want to Marry You | $4,011,433 | $9,217,837 | 43.5% | 492 | $8,153 | Feb 12, 2010 | Medusa Distribuzione |
| 178 | Quantum of Solace | $3,978,050 | $9,174,615 | 43.4% | 491 | $8,101 | Nov 7, 2008 | Sony Pictures Releasing |
| 179 | Citizen Rosi | $3,967,379 | $4,078,034 | 97.3% | - | - | Nov 18, 2019 | Istituto Luce Cinecittà |
| 180 | The Addams Family | $3,948,089 | $7,192,896 | 54.9% | 460 | $8,582 | Oct 31, 2019 | Eagle Pictures |
| 181 | Shark Tale | $3,945,692 | $11,790,369 | 33.5% | 401 | $9,839 | Feb 25, 2005 | United International Pictures |
| 182 | Tell Me About Love | $3,911,534 | $11,537,025 | 33.9% | 595 | $6,574 | Feb 15, 2008 | 01 Distribution |
| 183 | The Croods | $3,908,695 | $15,148,219 | 25.8% | 711 | $5,497 | Mar 21, 2013 | 20th Century Fox International |
| 184 | Cars 2 | $3,876,944 | $14,421,348 | 26.9% | 834 | $4,648 | Jun 22, 2011 | Walt Disney Pictures |
| 185 | The Curious Case of Benjamin Button | $3,871,237 | $15,750,900 | 24.6% | 477 | $8,115 | Feb 13, 2009 | Warner Bros. |
| 186 | Transformers: Age of Extinction | $3,866,322 | $11,598,181 | 33.3% | 850 | $4,548 | Jul 16, 2014 | United International Pictures |
| 187 | Murder on the Orient Express | $3,844,701 | $17,686,390 | 21.7% | 598 | $6,429 | Nov 30, 2017 | 20th Century Fox International |
| 188 | Jumanji: Welcome to the Jungle | $3,844,050 | $12,704,618 | 30.3% | 456 | $8,429 | Jan 1, 2018 | Sony Pictures Releasing |
| 189 | The Hateful Eight | $3,821,731 | $9,183,988 | 41.6% | 643 | $5,943 | Feb 4, 2016 | 01 Distribution |
| 190 | Genitori & figli:) - Agitare bene prima dell'uso | $3,802,776 | $11,455,266 | 33.2% | 471 | $8,073 | Feb 26, 2010 | Filmauro |
| 191 | To Rome with Love | $3,780,781 | $9,565,012 | 39.5% | 603 | $6,269 | Apr 20, 2012 | Medusa Distribuzione |
| 192 | Oz the Great and Powerful | $3,763,214 | $10,420,037 | 36.1% | 588 | $6,400 | Mar 7, 2013 | Walt Disney Pictures |
| 193 | The Great Gatsby | $3,753,759 | $9,366,454 | 40.1% | 747 | $5,025 | May 16, 2013 | Warner Bros. |
| 194 | Eternals | $3,753,091 | $9,766,392 | 38.4% | 467 | $8,036 | Nov 3, 2021 | Walt Disney Studios Motion Pictures |
| 195 | Perfect Strangers | $3,744,641 | $19,630,803 | 19.1% | 526 | $7,119 | Feb 11, 2016 | Medusa Distribuzione |
| 196 | Dumbo | $3,742,611 | $12,263,158 | 30.5% | 834 | $4,487 | Mar 28, 2019 | Walt Disney Pictures |
| 197 | The Tiger and the Snow | $3,740,934 | $17,451,649 | 21.4% | 754 | $4,961 | Oct 14, 2005 | 01 Distribution |
| 198 | Rocky Balboa | $3,727,526 | $8,928,978 | 41.8% | 331 | $11,261 | Jan 12, 2007 | 20th Century Fox International |
| 199 | After | $3,714,875 | $7,126,110 | 52.1% | 606 | $6,130 | Apr 11, 2019 | - |
| 200 | Alexander | $3,708,917 | $10,831,258 | 34.2% | 446 | $8,315 | Jan 14, 2005 | Warner Bros. |
